Article
Generation of gene-corrected iPSCs line (KEIUi001-A) from a PARK8 patient iPSCs with familial Parkinson's disease carrying the I2020T mutation in LRRK2.
Stem cell research - 1 Dec 2020
Ohta Etsuro, Sone Takefumi, Ukai Hideki, Hisamatsu Tomoko, Kitagawa Tokiko, Ishikawa Mitsuru, Nagai Makiko, Ueda Hiroki R, Obata Fumiya, Okano Hideyuki
Abstract excerpt
Leucine-rich repeat kinase 2 (LRRK2) is the causal gene of the autosomal dominant hereditary form of Parkinson's disease (PD), PARK8. We have previously reported that induced pluripotent stem cells (iPSCs) from a PARK8 patient with I2020T LRRK2 mutation replicated to some extent the pathologic phenotype evident in the brain of PD patients. In the present study, we generated gene-corrected iPSCs line, KEIUi001-A,...
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