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Article

Mechanosensitive smooth muscle cell phenotypic plasticity emerging from a null state and the balance between Rac and Rho.

Cell reports - 20 Apr 2021

Talwar Shefali, Kant Aayush, Xu Tina, Shenoy Vivek B, Assoian Richard K

Abstract excerpt

Reversible differentiation of vascular smooth muscle cells (VSMCs) plays a critical role in vascular biology and disease. Changes in VSMC differentiation correlate with stiffness of the arterial extracellular matrix (ECM), but causal relationships remain unclear. We show that VSMC plasticity is mechanosensitive and that both the de-differentiated and differentiated fates are promoted by the same ECM stiffness....

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Share to Mechanotransduction, Cellular
Share to Myocytes, Smooth Muscle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to rac1 GTP-Binding Protein

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Source

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Identifiers

PMID: 33882318
DOI: 10.1016/j.celrep.2021.109019
PMCID: PMC8142933

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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