Article
Association between TNF promoter -308 G>A and LTA 252 A>G polymorphisms and systemic lupus erythematosus.
Molecular biology reports - 1 Jan 2014
Ahmed Hanan Hosni, Taha Fatma Mohamed, Darweesh Hanan El-Sayed, Morsi Heba Mohamed Abdelhafiz
Abstract excerpt
Tumor necrosis factor (TNF) and lymphotoxin alpha (LTA) are pivotal cytokines in the pathogenesis of systemic lupus erythematosus (SLE). To investigate the possible association of the polymorphism of the TNF promoter gene -308 and that of the LTA gene 252 with susceptibility to SLE and with phenotypic disease features in Egyptian patients. A case control study involving 100 SLE patients and 100 unrelated healthy...
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