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Article

Polymorphisms in the TP53-MDM2-MDM4-axis in patients with rheumatoid arthritis.

Gene - 15 Aug 2021

Gansmo Liv B, Lie Benedicte A, Mæhlen Marthe T, Vatten Lars, Romundstad Pål, Hveem Kristian, Lønning Per E, Knappskog Stian

Abstract excerpt

BACKGROUND: In addition to being a tumour suppressor, TP53 is a suppressor of inflammation, and dysfunction of this gene has been related to autoimmune diseases. Patients with autoimmunity, such as rheumatoid arthritis (RA) have an increased risk of certain cancers, like lymphomas, indicating that some underlying mechanisms may modulate risk of both cancers and autoimmunity. METHODS: We genotyped 5 common genetic...

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Identifiers

PMID: 34077778
DOI: 10.1016/j.gene.2021.145747

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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