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Article

Different apoptotic responses of RA synoviocytes depending on different genotypes of the mdm2 SNP T309G.

Apoptosis : an international journal on programmed cell death - 1 Apr 2012

Heyne Kristina, Huwer Judith, Zimmer Vincent, Pfreundschuh Michael, Ney Jasmin Teresa, Assmann Gunter

Abstract excerpt

Mdm2 is an ubiquitin ligase, which binds p53 and blocks its function as a transcription factor in the pathway of apoptosis. Recently we have showed that the SNP mdm2 T309G has a protective effect of the minor allele in rheumatoid arthritis (RA). However, a functional impact on apoptosis by the different genotypes of the mdm2 SNP has not been investigated. Genomic DNA was obtained from 49 cell lines of...

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PMID: 22187011
DOI: 10.1007/s10495-011-0689-7

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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