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Article

Differential effect of clopidogrel and ticagrelor on leukocyte count in relation to patient characteristics, biomarkers and genotype: a PLATO substudy.

Platelets - 3 Apr 2022

Nelson Thomas A, Parker William A E, Ghukasyan Lakic Tatevik, Westerbergh Johan, James Stefan K, Siegbahn Agneta, Becker Richard C, Himmelmann Anders, Wallentin Lars, Storey Robert F

Abstract excerpt

Inflammation plays a key role in cardiovascular disease by contributing to atherothrombosis. The PLATelet inhibition and patient Outcomes (PLATO) study (NCT00391872) compared ticagrelor to clopidogrel in patients with acute coronary syndromes and demonstrated fewer cardiovascular events with ticagrelor but lower white blood cell counts (WBC) with clopidogrel. In this further analysis of the PLATO biomarker...

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Identifiers

PMID: 34077291
DOI: 10.1080/09537104.2021.1934667

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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