Article
Combined effects of clonal hematopoiesis of indeterminate potential and P2Y12 inhibitors on outcomes of patients with ST-segment elevation myocardial infarction: A prospective study.
Pharmacological research - 1 Sept 2025
Chen Runzhen, Li Jiannan, Yan Shaodi, Zhao Xiaoxiao, Zhou Jinying, Li Nan, Xue Linghan, Liu Weida, Zhou Peng, Liu Chen, Chen Yi, Tan Yu, Song Li, Yan Hongbing, Zhao Hanjun
Abstract excerpt
Clonal hematopoiesis of indeterminate potential (CHIP) is a prominent risk factor for atherosclerosis, but effective medications for CHIP-associated risk are still lacking. This study aimed to assess prognostic impacts of P2Y12 inhibitors in the context of CHIP with a prospective cohort of 1332 patients of ST-segment elevation myocardial infarction (STEMI). Using targeted deep sequencing, CHIP was defined by any...
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