Article
Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLATO trial.
Lancet (London, England) - 16 Oct 2010
Wallentin Lars, James Stefan, Storey Robert F, Armstrong Martin, Barratt Bryan J, Horrow Jay, Husted Steen, Katus Hugo, Steg P Gabriel, Shah Svati H, Becker Richard C
Abstract excerpt
BACKGROUND: In the PLATO trial of ticagrelor versus clopidogrel for treatment of acute coronary syndromes, ticagrelor reduced the composite outcome of cardiovascular death, myocardial infarction, and stroke, but increased events of major bleeding related to non-coronary artery bypass graft (CABG). CYP2C19 and ABCB1 genotypes are known to influence the effects of clopidogrel. In this substudy, we investigated the...
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