Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting drugs to APJ receptor: the prospect of treatment of hypertension and other cardiovascular diseases.

Current drug targets - 1 Jan 2015

Cao Jiangang, Li Hening, Chen Linxi

Abstract excerpt

The APJ is a class A, rhodopsin-like G protein-coupled receptor (GPCR) with high sequence similarity to the angiotensin receptor AT1. APJ has been shown to be widely expressed in humans tissues, including the central nervous system, cardiovascular system, adipocytes and others. APJ plays an important role in the occurrence and development of cardiovascular and metabolic diseases including atherosclerosis (AS),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiovascular Agents
Share to Cardiovascular Diseases
Share to Drug Design

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypertension

Share to Molecular Structure

Share to Molecular Targeted Therapy

Share to Receptors, G-Protein-Coupled

Share to Small Molecule Libraries

Source

Identifiers

PMID: 25438973
DOI: 10.2174/1389450115666141128120053

Genes

CAD
PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting drugs to APJ receptor: the prospect of treatment of hypertension and other cardiovascular diseases.PMID 25438973Read ↗

Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo.Semantic proximity Read ↗

Characterization of Apelin, the Ligand for the APJ ReceptorSemantic proximity Read ↗

Critical APJ receptor residues in extracellular domains that influence effector selectivity.Semantic proximity Read ↗

Apelin/APJ: Another Player in the Cancer Biology NetworkSemantic proximity Read ↗

APJ polymorphisms in coronary artery disease patients with and without hypertension.Semantic proximity Read ↗

An overview of alamadine/MrgD signaling and its role in cardiomyocytesSemantic proximity Read ↗

Associations between gene polymorphisms of the apelin-APJ system and the risk of hypertension.Semantic proximity Read ↗

A network map of apelin-mediated signalingSemantic proximity Read ↗

Reduced plasma APJ levels and APLNR G212A polymorphism in Syrian patients with coronary artery disease.Semantic proximity Read ↗

Association of SNP Rs9943582 in APLNR with Left Ventricle Systolic Dysfunction in Patients with Coronary Artery Disease in a Chinese Han GeneID Population.Semantic proximity Read ↗

Identification of serine 348 on the apelin receptor as a novel regulatory phosphorylation site in apelin-13-induced G protein-independent biased signaling.Semantic proximity Read ↗

A mini review on glucagon-like peptide-1 receptor agonists and its role in blood pressure regulationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.