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Article

Genome editing in mammalian cells using the CRISPR type I-D nuclease.

Nucleic acids research - 21 Jun 2021

Osakabe Keishi, Wada Naoki, Murakami Emi, Miyashita Naoyuki, Osakabe Yuriko

Abstract excerpt

Adoption of CRISPR-Cas systems, such as CRISPR-Cas9 and CRISPR-Cas12a, has revolutionized genome engineering in recent years; however, application of genome editing with CRISPR type I-the most abundant CRISPR system in bacteria-remains less developed. Type I systems, such as type I-E, and I-F, comprise the CRISPR-associated complex for antiviral defense ('Cascade': Cas5, Cas6, Cas7, Cas8 and the small subunit)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34076237
DOI: 10.1093/nar/gkab348
PMCID: PMC8216271

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