Article
Differential expression of both extracellular and intracellular proteins is involved in the lethal or nonlethal phenotypic variation of BrtlIV, a murine model for osteogenesis imperfecta.
Proteomics - 1 Jun 2007
Forlino Antonella, Tani Chiara, Rossi Antonio, Lupi Anna, Campari Elena, Gualeni Benedetta, Bianchi Laura, Armini Alessandro, Cetta Giuseppe, Bini Luca, Marini Joan C
Abstract excerpt
This study used proteomic and transcriptomic techniques to understand the molecular basis of the phenotypic variability in the bone disorder osteogenesis imperfecta (OI). Calvarial bone mRNA expression was evaluated by microarray, real-time, and comparative RT-PCR and the bone proteome profile wa...
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