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Article

Signaling pathways affected by mutations causing osteogenesis imperfecta.

Cellular signalling - 1 Dec 2020

Etich Julia, Rehberg Mirko, Eckes Beate, Sengle Gerhard, Semler Oliver, Zaucke Frank

Abstract excerpt

Osteogenesis imperfecta (OI) is a clinically and genetically heterogeneous connective tissue disorder characterized by bone fragility and skeletal deformity. To maintain skeletal strength and integrity, bone undergoes constant remodeling of its extracellular matrix (ECM) tightly controlled by osteoclast-mediated bone resorption and osteoblast-mediated bone formation. There are at least 20 recognized OI-forms...

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Identifiers

PMID: 32980496
DOI: 10.1016/j.cellsig.2020.109789

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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