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Article

Leukemia Cell Lines: In Vitro Models for the Study of Chronic Neutrophilic Leukemia.

Current oncology (Toronto, Ont.) - 10 May 2021

Drexler Hans G, Nagel Stefan, Quentmeier Hilmar

Abstract excerpt

Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative neoplasm that is genetically characterized by the absence of both the Philadelphia chromosome and BCR-ABL1 fusion gene and the high prevalence of mutations in the colony-stimulating factor 3 receptor (CSF3R). Additional disease-modifying mutations have been recognized in CNL samples, portraying a distinct mutational landscape. Despite the growing...

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Identifiers

PMID: 34068566
DOI: 10.3390/curroncol28030166
PMCID: PMC8161829

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