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Article

The Blockade of Tumoral IL1β-Mediated Signaling in Normal Colonic Fibroblasts Sensitizes Tumor Cells to Chemotherapy and Prevents Inflammatory CAF Activation.

International journal of molecular sciences - 7 May 2021

Díaz-Maroto Natalia Guillén, Garcia-Vicién Gemma, Polcaro Giovanna, Bañuls María, Albert Nerea, Villanueva Alberto, Molleví David G

Abstract excerpt

Heterotypic interactions between newly transformed cells and normal surrounding cells define tumor's fate in incipient carcinomas. Once homeostasis has been lost, normal resident fibroblasts become carcinoma-associated fibroblasts, conferring protumorogenic properties on these normal cells. Here we describe the IL1β-mediated interplay between cancer cells and normal colonic myofibroblasts (NCFs), which bestows...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34066976
DOI: 10.3390/ijms22094960
PMCID: PMC8125420

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