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Article

SIRT5 Inhibition Induces Brown Fat-Like Phenotype in 3T3-L1 Preadipocytes.

Cells - 7 May 2021

Molinari Francesca, Feraco Alessandra, Mirabilii Simone, Saladini Serena, Sansone Luigi, Vernucci Enza, Tomaselli Giada, Marzolla Vincenzo, Rotili Dante, Russo Matteo A, Ricciardi Maria Rosaria, Tafuri Agostino, Mai Antonello, Caprio Massimiliano, Tafani Marco, Armani Andrea

Abstract excerpt

Brown adipose tissue (BAT) activity plays a key role in regulating systemic energy. The activation of BAT results in increased energy expenditure, making this tissue an attractive pharmacological target for therapies against obesity and type 2 diabetes. Sirtuin 5 (SIRT5) affects BAT function by regulating adipogenic transcription factor expression and mitochondrial respiration. We analyzed the expression of SIRT5...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34066961
DOI: 10.3390/cells10051126
PMCID: PMC8148511

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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