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Article

Properties of Non-Aminoglycoside Compounds Used to Stimulate Translational Readthrough of PTC Mutations in Primary Ciliary Dyskinesia.

International journal of molecular sciences - 7 May 2021

Dabrowski Maciej, Bukowy-Bieryllo Zuzanna, Jackson Claire L, Zietkiewicz Ewa

Abstract excerpt

Primary ciliary dyskinesia (PCD) is a rare disease with autosomal recessive inheritance, caused mostly by bi-allelic gene mutations that impair motile cilia structure and function. Currently, there are no causal treatments for PCD. In many disease models, translational readthrough of premature termination codons (PTC-readthrough) induced by aminoglycosides has been proposed as an effective way of restoring...

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PMID: 34066907
DOI: 10.3390/ijms22094923
PMCID: PMC8125088

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