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Article

Aminoglycoside-stimulated readthrough of premature termination codons in selected genes involved in primary ciliary dyskinesia.

RNA biology - 2 Oct 2016

Bukowy-Bieryllo Zuzanna, Dabrowski Maciej, Witt Michał, Zietkiewicz Ewa

Abstract excerpt

Translational readthrough of premature termination codons (PTCs) induced by pharmacological compounds has proven to be an effective way of restoring functional protein expression and reducing symptoms in several genetic disorders. We tested the potential of different concentrations of several aminoglycosides (AAGs) for promoting PTC-readthrough in 5 genes involved in the pathogenesis of primary ciliary...

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Identifiers

PMID: 27618201
DOI: 10.1080/15476286.2016.1219832
PMCID: PMC5056772

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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