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Article

Molecular Insights into Determinants of Translational Readthrough and Implications for Nonsense Suppression Approaches.

International journal of molecular sciences - 11 Dec 2020

Lombardi Silvia, Testa Maria Francesca, Pinotti Mirko, Branchini Alessio

Abstract excerpt

The fidelity of protein synthesis, a process shaped by several mechanisms involving specialized ribosome regions and external factors, ensures the precise reading of sense and stop codons. However, premature termination codons (PTCs) arising from mutations may, at low frequency, be misrecognized and result in PTC suppression, named ribosome readthrough, with production of full-length proteins through the...

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Identifiers

PMID: 33322589
DOI: 10.3390/ijms21249449
PMCID: PMC7764779

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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