Article
Antimicrobial Activities of LL-37 Fragment Mutant-Poly (Lactic-Co-Glycolic) Acid Conjugate against Staphylococcus aureus, Escherichia coli, and Candida albicans.
International journal of molecular sciences - 12 May 2021
Mori Takeshi, Yoshida Miyako, Hazekawa Mai, Ishibashi Daisuke, Hatanaka Yoshiro, Nagao Toshihiro, Kakehashi Rie, Kojima Honami, Uno Rio, Ozeki Minoru, Kawasaki Ikuo, Yamashita Taku, Nishikawa Junichi, Uchida Takahiro
Abstract excerpt
Various peptides and their derivatives have been reported to exhibit antimicrobial activities. Although these activities have been examined against microorganisms, novel methods have recently emerged for conjugation of the biomaterials to improve their activities. Here, we prepared CKR12-PLGA, in which CKR12 (a mutated fragment of human cathelicidin peptide, LL-37) was conjugated with poly (lactic-co-glycolic)...
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