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Article

Aging Affects the Transcriptional Regulation of Human Skeletal Muscle Disuse Atrophy

19 Dec 2012

Abstract excerpt

Important insights concerning the molecular basis of skeletal muscle disuse-atrophy and aging related muscle loss have been obtained in cell culture and animal models, but these regulatory signaling pathways have not previously been studied in aging human muscle. In the present study, muscle atrophy was induced by immobilization in healthy old and young individuals to study the time-course and transcriptional...

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PMID: 23284670
DOI: 10.1371/journal.pone.0051238

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