Coxsackievirus A6 2C protein antagonizes IFN-β production through MDA5 and RIG-I depletion

Abstract excerpt

ABSTRACT As a member of the enteroviruses, coxsackievirus A6 (CV-A6) has been a major cause of hand, foot, and mouth disease (HFMD) since 2008. It can infect both pediatric and adult populations, often leading to atypical HFMD. The host innate immune system plays a vital role in the development of enteroviral infections. However, the interplay between the host antiviral response and CV-A6 has not been well...

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