Article
Identification of genes associated with the corticotroph phenotype in bronchial carcinoid tumors.
The Journal of clinical endocrinology and metabolism - 1 Nov 2002
Pascual-Le Tallec Laurent, Dulmet Elisabeth, Bertagna Xavier, de Keyzer Yves
Abstract excerpt
The proopiomelanocortin (POMC) gene is occasionally expressed in nonpituitary tumors leading to Cushing's syndrome. Bronchial carcinoid tumors, one of the most frequent source for ectopic ACTH secretion, often display numerous features of the corticotroph phenotype. To identify new markers of corticotroph differentiation in these tumors, we compared the pattern of gene expression in ACTH-secreting (ACTH+) and...
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