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PB2 mutations arising during H9N2 influenza evolution in the Middle East confer enhanced replication and growth in mammals

2 Jul 2019

Abstract excerpt

Avian influenza virus H9N2 has been endemic in birds in the Middle East, in particular in Egypt with multiple cases of human infections since 1998.Despite concerns about the pandemic threat posed by H9N2, little is known about the biological properties of H9N2 in this epicentre of infection.Here, we investigated the evolutionary dynamics of H9N2 in the Middle East and identified phylogeny-associated PB2 mutations...

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PMID: 31265471
DOI: 10.1371/journal.ppat.1007919

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