Article
A Melanocortin-4 Receptor Agonist Induces Skin and Hair Pigmentation in Patients with Monogenic Mutations in the Leptin-Melanocortin Pathway.
Skin pharmacology and physiology - 1 Jan 2021
Kanti Varvara, Puder Lia, Jahnke Irina, Krabusch Philipp Maximilian, Kottner Jan, Vogt Annika, Richter Claudia, Andruck Annette, Lechner Lara, Poitou Christine, Krude Heiko, Gottesdiener Keith, Clément Karine, Farooqi Ismaa Sadaf, Wiegand Susanna, Kühnen Peter, Blume-Peytavi Ulrike
Abstract excerpt
BACKGROUND AND OBJECTIVES: Gene mutations within the leptin-melanocortin signaling pathway lead to severe early-onset obesity. Recently, a phase 2 trial evaluated new pharmacological treatment options with the MC4R agonist setmelanotide in patients with mutations in the genes encoding proopiomelanocortin (POMC) and leptin receptor (LEPR). During treatment with setmelanotide, changes in skin pigmentation were...
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