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Article

Proopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist.

The New England journal of medicine - 21 Jul 2016

Kühnen Peter, Clément Karine, Wiegand Susanna, Blankenstein Oliver, Gottesdiener Keith, Martini Lea L, Mai Knut, Blume-Peytavi Ulrike, Grüters Annette, Krude Heiko

Abstract excerpt

Patients with rare defects in the gene encoding proopiomelanocortin (POMC) have extreme early-onset obesity, hyperphagia, hypopigmentation, and hypocortisolism, resulting from the lack of the proopiomelanocortin-derived peptides melanocyte-stimulating hormone and corticotropin. In such patients, adrenal insufficiency must be treated with hydrocortisone early in life. No effective pharmacologic treatments have...

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Identifiers

PMID: 27468060
DOI: 10.1056/NEJMoa1512693

Genes

POMC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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