Article
High manganese, a risk for Alzheimer's disease: high manganese induces amyloid-β related cognitive impairment.
Journal of Alzheimer's disease : JAD - 1 Jan 2014
Tong Yawei, Yang Huan, Tian Xiaosheng, Wang Hecheng, Zhou Ting, Zhang Shouzi, Yu Jia, Zhang Tao, Fan Dongshen, Guo Xiangyang, Tabira Takeshi, Kong Fanjun, Chen Zheng, Xiao Weizhong, Chui Dehua
Abstract excerpt
Excess manganese (Mn) in brain can be neurotoxic, implicated in several neurodegenerative disorders such as sporadic Alzheimer's disease (AD). However, little is known about the altered metal environment including elevated Mn in the progressive cognitive impairment of AD. Indeed, whether high Mn is associated with AD risk remains elusive. In the study, we recruited 40 Chinese elders with different cognitive...
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