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Article

The Association of Essential Metals with APOE Genotype in Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2021

Babić Leko Mirjana, Jurasović Jasna, Nikolac Perković Matea, Španić Ena, Sekovanić Ankica, Orct Tatjana, Lukinović Škudar Vesna, Bačić Baronica Koraljka, Kiđemet-Piskač Spomenka, Vogrinc Željka, Pivac Nela, Borovečki Fran, Hof Patrick R, Šimić Goran

Abstract excerpt

BACKGROUND: The major confirmed genetic risk factor for late-onset, sporadic Alzheimer's disease (AD) is variant ɛ4 of apolipoprotein E gene (APOE). It is proposed that ApoE, a protein involved in transport of cholesterol to neurons can cause neurodegeneration in AD through interaction with metals. Previous studies mostly associated copper, iron, zinc, and calcium with ApoE4-mediated toxicity. OBJECTIVE: To test...

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Identifiers

PMID: 34057084
DOI: 10.3233/JAD-210158

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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