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Article

Metallo-pathways to Alzheimer's disease: lessons from genetic disorders of copper trafficking.

Metallomics : integrated biometal science - 1 Sept 2016

Greenough M A, Ramírez Munoz A, Bush A I, Opazo C M

Abstract excerpt

Copper is an essential metal ion that provides catalytic function to numerous enzymes and also regulates neurotransmission and intracellular signaling. Conversely, a deficiency or excess of copper can cause chronic disease in humans. Menkes and Wilson disease are two rare heritable disorders of copper transport that are characterized by copper deficiency and copper overload, respectively. Changes to copper status...

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PMID: 27397642
DOI: 10.1039/c6mt00095a

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