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Validation of a methylation-based signature for subventricular zone involvement in glioblastoma

20 Feb 2024

Abstract excerpt

PURPOSE: Glioblastomas (GBM) with subventricular zone (SVZ) contact have previously been associated with a specific epigenetic fingerprint. We aim to validate a reported bulk methylation signature to determine SVZ contact. METHODS: Methylation array analysis was performed on IDHwt GBM patients treated at our institution. The v11b4 classifier was used to ensure the inclusion of only receptor tyrosine kinase (RTK)...

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Share to Epigenetics and DNA Methylation
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PMID: 38376766
DOI: 10.1007/s11060-024-04570-0

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