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Article

Characterization in Mice of the Resident Mesenchymal Niche Maintaining At2 Stem Cell Proliferation in Homeostasis and Disease

15 Jun 2021

Abstract excerpt

Abstract Resident mesenchymal cells (rMCs defined as Cd31NegCd45NegEpcamNeg) control the proliferation and differentiation of alveolar epithelial type 2 (AT2) stem cells in vitro. The identity of these rMCs is still elusive. Among them, Axin2Pos mesenchymal alveolar niche cells (MANCs), which are expressing Fgf7, have been previously described. We propose that an additional population of rMCs, expressing Fgf10...

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PMID: 34048616
DOI: 10.1002/stem.3423

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