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Evaluate the effects of serum urate level on bone mineral density: a genome-wide gene-environment interaction analysis in UK Biobank cohort.

Endocrine - 1 Sept 2021

Yao Yao, Chu Xiaomeng, Ma Mei, Ye Jing, Wen Yan, Li Ping, Cheng Bolun, Cheng Shiqiang, Zhang Lu, Liu Li, Qi Xin, Liang Chujun, Kafle Om Prakash, Wu Cuiyan, Wang Sen, Wang Xi, Ning Yujie, Zhang Feng

Abstract excerpt

INTRODUCTION: Serum urate is associated with BMD and may be a protective factor. However, the exact association and mechanism are still unclear. We performed a genome-wide gene-environmental interaction study (GWGEIS) to explore the interaction effects between gene and urate on BMD, using data from the UK Biobank cohort. METHODS: A total of 4575 participants for femur total BMD, 4561 participants for L1-L4 BMD,...

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PMID: 34046847
DOI: 10.1007/s12020-021-02760-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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