Article
Dynamic CTC phenotypes in metastatic prostate cancer models visualized using magnetic ranking cytometry.
Lab on a chip - 10 Jul 2018
Kermanshah Leyla, Poudineh Mahla, Ahmed Sharif, Nguyen L N Matthew, Srikant Sanjana, Makonnen Rhema, Pena Cantu Fernando, Corrigan Michael, Kelley Shana O
Abstract excerpt
Tumors can shed thousands of cells into the circulation daily. These circulating tumor cells (CTCs) are heterogeneous, and their phenotypes change dynamically. Real-time monitoring of CTC phenotypes is crucial to elucidate the role of CTCs in the metastatic cascade. Here, we monitor phenotypic changes in CTCs in mice xenografted with tumors with varying aggressiveness during cancer progression and a course of...
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