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Article

Peripheral blood basophils are the main source for early interleukin-4 secretion upon in vitro stimulation with Culicoides allergen in allergic horses.

PloS one - 1 Jan 2021

Raza Fahad, Babasyan Susanna, Larson Elisabeth M, Freer Heather S, Schnabel Christiane L, Wagner Bettina

Abstract excerpt

Interleukin-4 (IL-4) is a key cytokine secreted by type 2 T helper (Th2) cells that orchestrates immune responses during allergic reactions. Human and mouse studies additionally suggest that basophils have a unique role in the regulation of allergic diseases by providing initial IL-4 to drive T cell development towards the Th2 phenotype. Equine Culicoides hypersensitivity (CH) is a seasonal immunoglobulin E...

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Identifiers

PMID: 34038479
DOI: 10.1371/journal.pone.0252243
PMCID: PMC8153460

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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