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Article

Investigating the epithelial barrier and immune signatures in the pathogenesis of equine insect bite hypersensitivity

28 Apr 2020

Abstract excerpt

Insect bite hypersensitivity (IBH) is a Th-2, IgE-mediated dermatitis of horses caused by bites of insects of the genus Culicoides that has common features with human atopic dermatitis. Together with Th-2 cells, the epithelial barrier plays an important role in development of type I hypersensitivities. In order to elucidate the role of the epithelial barrier and of the skin immune response in IBH we studied the...

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PMID: 32343720
DOI: 10.1371/journal.pone.0232189

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