Article

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

2025-08-28

Abstract excerpt

<h4>ABSTRACT</h4> Acquired tick resistance (ATR) is well characterized in tick-exposed animals, compromising tick fitness through antibody-mediated activation of basophils. Yet, anti-tick vaccines inducing ATR have had limited success. Here, we describe a neuroimmune event preceding ATR that leads to rapid host-mediated tick removal. Tick-sensitized guinea pigs mechanically remove ticks within 3-6 hours via an ac...

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Identifiers and source

Literature Corpus work: 40ef317f-94bc-5053-8d3d-c40237dc8083
DOI: 10.1101/2025.08.22.671835

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