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Article

DOT1L modulates the senescence-associated secretory phenotype through epigenetic regulation of IL1A.

The Journal of cell biology - 2 Aug 2021

Leon Kelly E, Buj Raquel, Lesko Elizabeth, Dahl Erika S, Chen Chi-Wei, Tangudu Naveen Kumar, Imamura-Kawasawa Yuka, Kossenkov Andrew V, Hobbs Ryan P, Aird Katherine M

Abstract excerpt

Oncogene-induced senescence (OIS) is a stable cell cycle arrest that occurs in normal cells upon oncogene activation. Cells undergoing OIS express a wide variety of secreted factors that affect the senescent microenvironment termed the senescence-associated secretory phenotype (SASP), which is beneficial or detrimental in a context-dependent manner. OIS cells are also characterized by marked epigenetic changes....

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Identifiers

PMID: 34037658
DOI: 10.1083/jcb.202008101
PMCID: PMC8160577

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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