Article
Organization of the laminin polymer node.
Matrix biology : journal of the International Society for Matrix Biology - 1 Apr 2021
McKee Karen K, Hohenester Erhard, Aleksandrova Maya, Yurchenco Peter D
Abstract excerpt
Laminin polymerization is a key step of basement membrane assembly that depends on the binding of α, β and γ N-terminal LN domains to form a polymer node. Nodal assembly can be divided into two steps consisting of β- and γ-LN dimerization followed by calcium-dependent addition of the α-LN domain. The assembly and structural organization of laminin-111 LN-LEa segments was examined by size-exclusion chromatography...
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