Article
Distribution and isolation of four laminin variants; tissue restricted distribution of heterotrimers assembled from five different subunits.
Cell regulation - 1 Sept 1990
Engvall E, Earwicker D, Haaparanta T, Ruoslahti E, Sanes J R
Abstract excerpt
The distribution of subunits of the basement membrane proteins laminin and merosin in human and rabbit tissue was studied by immunofluorescence using monoclonal antibodies. The laminin A chain is present in epithelial, endothelial, and smooth muscle basement membranes. Merosin, as defined by its heavy chain M, is present in striated muscle and peripheral nerve. The A subunit colocalizes with at least two B...
Topics
- Animals
- Antibodies, Monoclonal
- Chorionic Villi
- Enzyme-Linked Immunosorbent Assay
- Female
- Fluorescent Antibody Technique
- Genetic Variation
- Humans
- Laminin
- Macromolecular Substances
- Membrane Proteins