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Article

Erythrocyte CD55 mediates the internalization of Plasmodium falciparum parasites

24 May 2021

Abstract excerpt

host factors identified erythrocyte CD55 as essential for invasion, but its specific role and how it interfaces with the other factors that mediate this complex process are unknown. Using CRISPR-Cas9 editing, antibody-based inhibition, and live cell imaging, here we show that CD55 is specifically required for parasite internalization. Pre-invasion kinetics, erythrocyte deformability, and echinocytosis were not...

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PMID: 34028351
DOI: 10.7554/elife.61516

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