Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A forward genetic screen identifies erythrocyte CD55 as essential for <i>Plasmodium falciparum</i> invasion

7 May 2015

Abstract excerpt

Efforts to identify host determinants for malaria have been hindered by the absence of a nucleus in erythrocytes, which precludes genetic manipulation in the cell in which the parasite replicates. We used cultured red blood cells derived from hematopoietic stem cells to carry out a forward genetic screen for Plasmodium falciparum host determinants. We found that CD55 is an essential host factor for P. falciparum...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complement system in diseases
Share to Malaria Research and Control
Share to Mosquito-borne diseases and control

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25954012
DOI: 10.1126/science.aaa3526

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A forward genetic screen identifies erythrocyte CD55 as essential for <i>Plasmodium falciparum</i> invasionPMID 25954012Read ↗

Erythrocyte CD55 facilitates the internalization of <i>Plasmodium falciparum</i> parasitesSemantic proximity Read ↗

<i>Plasmodium falciparum</i> exploits CD44 as a co-receptor for erythrocyte invasionSemantic proximity Read ↗

Plasmodium falciparum exploits CD44 as a coreceptor for erythrocyte invasionSemantic proximity Read ↗

Erythrocyte CD55 mediates the internalization of Plasmodium falciparum parasitesSemantic proximity Read ↗

In Vitro Genetic Analysis of an Erythrocyte Determinant of Malaria InfectionSemantic proximity Read ↗

A systematic targeted genetic screen identifies proteins involved in cytoadherence of the malaria parasite <i>P. falciparum</i>Semantic proximity Read ↗

A flow cytometry‐based assay for measuring invasion of red blood cells by <i>Plasmodium falciparum</i>Semantic proximity Read ↗

An adaptable two‐color flow cytometric assay to quantitate the invasion of erythrocytes by <i>Plasmodium falciparum</i> parasitesSemantic proximity Read ↗

Genetic manipulation of cell line derived reticulocytes enables dissection of host malaria invasion requirementsSemantic proximity Read ↗

CRISPR/Cas9 genome editing to generate single variant <i>Plasmodium falciparum</i> lines and enable reverse genetic studies of PfEMP1 function in live parasitesSemantic proximity Read ↗

The influence of host genetics on erythrocytes and malaria infection: is there therapeutic potential?Semantic proximity Read ↗

Blood donor variability is a modulatory factor for <i>P. falciparum</i> invasion phenotyping assaysSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.