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Article

Genomic trajectory in leukemogenesis of myeloproliferative neoplasms: a case report.

BMC medical genomics - 22 May 2021

Chen Yujie, Talukder Rafee, Merritt Brian Y, King Katherine Y, Kimmel Marek, Rivero Gustavo, Sosa Romina

Abstract excerpt

BACKGROUND: We report a patient with Essential Thrombocythemia (ET), subsequently diagnosed with concurrent myeloid and lymphoid leukemia. Generally, the molecular mechanisms underlying leukemic transformation of Philadelphia-negative myeloproliferative neoplasms (Ph-MPN) are poorly understood. Risk of transformation to acute myelogenous leukemia (AML) is low; transformation to both AML and acute lymphoblastic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, B-Cell

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Share to Myeloproliferative Disorders

Share to Thrombocythemia, Essential

Source

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Identifiers

PMID: 34022887
DOI: 10.1186/s12920-021-00986-z
PMCID: PMC8141236

Genes

ASXL1
JAK2
SF3B1
TET2
TP53

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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