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Characterization of myeloproliferative neoplasms based on genetics only and prognostication of transformation to blast phase.

Leukemia - 1 Dec 2024

Walter Wencke, Nadarajah Niroshan, Hutter Stephan, Müller Heiko, Haferlach Claudia, Kern Wolfgang, Haferlach Torsten, Meggendorfer Manja

Abstract excerpt

Myeloproliferative neoplasms (MPN) are a heterogeneous group of clonal disorders characterized by aberrant hematopoietic proliferation and an intrinsic risk of progression to blast phase. The WHO classification 2022 identifies chronic myeloid leukemia and the BCR::ABL1 negative MPNs polycythemia vera, primary myelofibrosis and essential thrombocythemia as individual entities. However, overlaps, borderline...

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Aged
Biomarkers, Tumor
Blast Crisis
Cell Transformation, Neoplastic
Disease Progression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myeloproliferative Disorders

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Identifiers

PMID: 39341969
DOI: 10.1038/s41375-024-02425-1
PMCID: PMC11588659

Genes

ABL1
BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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