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Article

Stratifying Multiple Sclerosis Susceptibility Risk: The Role of HLA-E*01 and Infectious Mononucleosis in a Population Cohort.

European journal of neurology - 1 Apr 2025

Nova Andrea, Gentilini Davide, Di Caprio Giovanni, Bourguiba-Hachemi Sonia, Vince Nicolas, Gourraud Pierre-Antoine, Bernardinelli Luisa, Fazia Teresa

Abstract excerpt

BACKGROUND: Epstein-Barr Virus (EBV) and its clinical manifestation, infectious mononucleosis (IM), are strongly linked to MS risk. A recent in vitro study suggests that HLA-E*01:03, in contrast to HLA-E*01:01, may protect against MS through more effective immune responses against EBV-infected B cells. However, the role of HLA-E*01 in MS remains unclear. METHODS: We investigated if HLA-E*01:01 was significantly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40192262
DOI: 10.1111/ene.70131
PMCID: PMC11973926

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