Article
Determinants of telomere length across human tissues.
Science (New York, N.Y.) - 11 Sept 2020
Demanelis Kathryn, Jasmine Farzana, Chen Lin S, Chernoff Meytal, Tong Lin, Delgado Dayana, Zhang Chenan, Shinkle Justin, Sabarinathan Mekala, Lin Hannah, Ramirez Eduardo, Oliva Meritxell, Kim-Hellmuth Sarah, Stranger Barbara E, Lai Tsung-Po, Aviv Abraham, Ardlie Kristin G, Aguet François, Ahsan Habibul, Doherty Jennifer A, Kibriya Muhammad G, Pierce Brandon L
Abstract excerpt
Telomere shortening is a hallmark of aging. Telomere length (TL) in blood cells has been studied extensively as a biomarker of human aging and disease; however, little is known regarding variability in TL in nonblood, disease-relevant tissue types. Here, we characterize variability in TLs from 6391 tissue samples, representing >20 tissue types and 952 individuals from the Genotype-Tissue Expression (GTEx)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.