Article
Prevalence and molecular characterization of pertactin-deficient Bordetella pertussis in the United States.
Clinical and vaccine immunology : CVI - 1 Feb 2014
Pawloski L C, Queenan A M, Cassiday P K, Lynch A S, Harrison M J, Shang W, Williams M M, Bowden K E, Burgos-Rivera B, Qin X, Messonnier N, Tondella M L
Abstract excerpt
Pertussis has shown a striking resurgence in the United States, with a return to record numbers of reported cases as last observed in the 1950s. Bordetella pertussis isolates lacking pertactin, a key antigen component of the acellular pertussis vaccine, have been observed, suggesting that B. pertussis is losing pertactin in response to vaccine immunity. Screening of 1,300 isolates from outbreak and surveillance...
Topics
- Bacterial Outer Membrane Proteins
- Blotting, Western
- Bordetella pertussis
- Cluster Analysis
- DNA, Bacterial
- Electrophoresis, Gel, Pulsed-Field
- Genotype
- Humans
- Molecular Epidemiology
- Molecular Typing
- Mutation
- Polymerase Chain Reaction