Article
Screening and Genomic Characterization of Filamentous Hemagglutinin-Deficient Bordetella pertussis.
Infection and immunity - 1 Apr 2018
Weigand Michael R, Pawloski Lucia C, Peng Yanhui, Ju Hong, Burroughs Mark, Cassiday Pamela K, Davis Jamie K, DuVall Marina, Johnson Taccara, Juieng Phalasy, Knipe Kristen, Loparev Vladimir N, Mathis Marsenia H, Rowe Lori A, Sheth Mili, Williams Margaret M, Tondella M Lucia
Abstract excerpt
Despite high vaccine coverage, pertussis cases in the United States have increased over the last decade. Growing evidence suggests that disease resurgence results, in part, from genetic divergence of circulating strain populations away from vaccine references. The United States employs acellular vaccines exclusively, and current Bordetella pertussis isolates are predominantly deficient in at least one immunogen,...
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