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Article

Abortive intussusceptive angiogenesis causes multi-cavernous vascular malformations.

eLife - 20 May 2021

Li Wenqing, Tran Virginia, Shaked Iftach, Xue Belinda, Moore Thomas, Lightle Rhonda, Kleinfeld David, Awad Issam A, Ginsberg Mark H

Abstract excerpt

Mosaic inactivation of CCM2 in humans causes cerebral cavernous malformations (CCMs) containing adjacent dilated blood-filled multi-cavernous lesions. We used CRISPR-Cas9 mutagenesis to induce mosaic inactivation of zebrafish ccm2 resulting in a novel lethal multi-cavernous lesion in the embryonic caudal venous plexus (CVP) caused by obstruction of blood flow by intraluminal pillars. These pillars mimic those...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemangioma, Cavernous, Central Nervous System

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Source

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Identifiers

PMID: 34013885
DOI: 10.7554/eLife.62155
PMCID: PMC8175082

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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