Computational based design and tracking of synthetic variants of Porcine circovirus reveal relations between silent genomic information and viral fitness.

Abstract excerpt

Viral genomes not only code the protein content, but also include silent, overlapping codes which are important to the regulation of the viral life cycle and affect its evolution. Due to the high density of these codes, their non-modular nature and the complex intracellular processes they encode, the ability of current approaches to decipher them is very limited. We describe the first computational-experimental...

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