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Article

Algorithms for ribosome traffic engineering and their potential in improving host cells' titer and growth rate.

Scientific reports - 3 Dec 2020

Zur Hadas, Cohen-Kupiec Rachel, Vinokour Sophie, Tuller Tamir

Abstract excerpt

mRNA translation is a fundamental cellular process consuming most of the intracellular energy; thus, it is under extensive evolutionary selection for optimization, and its efficiency can affect the host's growth rate. We describe a generic approach for improving the growth rate (fitness) of any organism by introducing synonymous mutations based on comprehensive computational models. The algorithms introduce...

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Identifiers

PMID: 33273552
DOI: 10.1038/s41598-020-78260-y
PMCID: PMC7713304

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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