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Article

Investigating the impact of reference assembly choice on genomic analyses in a cattle breed.

BMC genomics - 19 May 2021

Lloret-Villas Audald, Bhati Meenu, Kadri Naveen Kumar, Fries Ruedi, Pausch Hubert

Abstract excerpt

BACKGROUND: Reference-guided read alignment and variant genotyping are prone to reference allele bias, particularly for samples that are greatly divergent from the reference genome. A Hereford-based assembly is the widely accepted bovine reference genome. Haplotype-resolved genomes that exceed the current bovine reference genome in quality and continuity have been assembled for different breeds of cattle. Using...

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PMID: 34011274
DOI: 10.1186/s12864-021-07554-w
PMCID: PMC8132449

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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